hrp0097s6.1 | Neonatal endocrinology | ESPE2023

Unravelling the role of epigenetics in reproductive adaptations to early-life environment

Melamed Philippa

Adult reproductive function is affected by early life environments and experiences, pointing to a possible role for epigenetic modifications in directing an adaptive response. Using mouse and cellular models, we have been studying the mechanisms underlying the shorter reproductive lifespan experienced by Bangladeshi women who grew up in Bangladesh as opposed to the UK, a phenotype associated specifically with the greater immune challenges in Bangladeshi childhood and altered D...